EFFECT OF THIAMINE DERIVATIVES ON THE OXYGEN UPTAKE OF AVITAMINOUS PIGEON BRAIN

Abstract

Although various thiamine derivatives have been available, effect of the substances on the nervous tissues is not yet clear. In this study, their effects upon the oxygen uptake were investigated according to Peters' catatorulin test, using the slices and homogenates of avitaminous pigeon brain. In an experiment with the slices, it was demonstrated that TPD, TTFD, TATD and TDS were more effective than thiamine hydrochloride in the oxygen uptake. It was also observed that CAT was less effective than the latter, showing little effect of TDP and BTMP. In another experiment with the homogenates, on the contrary, it was recognized that TDP markedly stimulated the oxidation of pyruvate, and the other derivatives above mentioned slightly stimulated similarly to thiamine hydrochloride. A slight inhibition of the effect was noted in the both slices and homogenates added the highly concentrated TPD and TATD, whereas it was not in the concentrated TDS. It appears that TDS is the most effective compound studied for the avitaminous brain.