ガン組織画分中のDPNH-diaphorase活性 : ガン化と活性の変化

抄録

Wattenberg observed that the DPNH-diaphorase activity was extremely high in proliferating region of cancer tissue of large intestine. We have assumed by a series of study that the microsomal DPNH-diaphorase activity might be concerned with cell mitosis in proliferating tissues. The present study was undertaken to compare the activity in subcellular components of cancer tissues of stomach and rectum to the activity of the originating respective normal mucosa. The following results were obtained : The mitochondrial DPNH-diaphorase activity was lower in cancer tissue than in normal mucosa of either stomach or rectum. On the contrary, the microsomal DPNH-diaphorase activity was higher in cancer tissue. Such results are supposed to support the above mentioned author's assumption.