Abstract
From the biological interest, five O, S-dicholanoylthiamine derivatives (I-V) were synthesised by the reaction of corresponding cholanoyl chloride with thiamine in alkaline medium. The compounds obtained here are insoluble in water and soluble in chloroform or ethyl acetate. These compounds are negative to thiochrome reaction, but become positive after treatment with alkali. The regeneration of thiamine and cholanic acid was shown. Biological test are now undertaken.
