Abstract
The authors had reported in the previous paper the affinity of TPD-^<35>S (inner), TPD-^<35>S (outer) and thiamine-^<35>S to the tissues after a single injection in animals. In the present study the accumulation of ^<35>S in the tissues and the replacement of thiamine after continuous administration of TPD-^<35>S (inner), TPD-^<35>S (outer) and thiamine-^<35>S were investigated. It was clarified that the increasing of accumulation of ^<35>S in the tissues was not found even if TPD-^<35>S (outer) was given subcutaneously every day consecutively for ten days, while the accumulation of ^<35>S was remarkable when in the case of TPD-^<35>S (inner). The replacement ratio of thiamine was higher in the heart and brain than that of the other organs and turn over of ^<35>S was larger when TPD-^<35>S (inner) was administrated than in the case of thiamine-^<35>S.
