VITAMINS

Online ISSN : 2424-080X
Print ISSN : 0006-386X

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Volume 32, Issue 2

Displaying 1-43 of 43 articles from this issue

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STUDIES ON THE NUTRITIONAL VALUE OF ALLIUM PLANTS : (XIV) AFFINITY OF THIAMINE PROPYLDISULFIDE-^<35>S TO ORGANS

Sukenari SASAGAWA, Yoshinori ITOKAWA, Koh IKEDA

Article type: Article
1965Volume 32Issue 2 Pages 193-199
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_193

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One of the authors (Itokawa) had reported the distribution of ^<35>S in the blood after administration of TPD-^<35>S (inner) and TPD-^<35>S (outer) in the previous paper. In the present paper, the authors investigated the distribution and retention of ^<35>S in various organs in the body. After injection of TPD-^<35>S (outer), ^<35>S was found in the largest quantity in the kidney, followed in order by the blood, lung and liver. Distribution of the ^<35>S from TPD-^<35>S (inner), on the other hand, was most marked in the liver, followed by the spleen, small intestine, kidney and blood. After oral administration, the ^<35>S from TPD-^<35>S (inner) was found in the small intestine and liver in large quantities, while the increase in ^<35>S from TPD-^<35>S (outer) was not marked. The ^<35>S of TPD-^<35>S (inner) penetrated into the liver and heart at higher concentration and was retained for a longer time than the ^<35>S of TPD-^<35>S (outer>. In the blood and intestinal tract, however, this relation was reversed.

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STUDIES ON THE NUTRITIONAL VALUE OF ALLIUM PLANTS : (XIVI) THE TURNOVER OF THIAMINE IN ORGANS AFTER ADMINISTRATION OF THIAMINE PROPYLDISUFIDE-^<35>S OR THIAMINE-^<35>S

Sukenari SASAGAWA, Yoshinori ITOKAWA, Koh IKEDA

Article type: Article
1965Volume 32Issue 2 Pages 200-204
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_200

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The authors had reported in the previous paper the affinity of TPD-^<35>S (inner), TPD-^<35>S (outer) and thiamine-^<35>S to the tissues after a single injection in animals. In the present study the accumulation of ^<35>S in the tissues and the replacement of thiamine after continuous administration of TPD-^<35>S (inner), TPD-^<35>S (outer) and thiamine-^<35>S were investigated. It was clarified that the increasing of accumulation of ^<35>S in the tissues was not found even if TPD-^<35>S (outer) was given subcutaneously every day consecutively for ten days, while the accumulation of ^<35>S was remarkable when in the case of TPD-^<35>S (inner). The replacement ratio of thiamine was higher in the heart and brain than that of the other organs and turn over of ^<35>S was larger when TPD-^<35>S (inner) was administrated than in the case of thiamine-^<35>S.

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STUDIES ON THE NUTRITIONAL VALUE OF ALLIUM PLANTS : (XLVII) FORM OF THIAMINE IN THE ORGANS AND DISTRIBUTION OF ^<35>S IN SUBCELLULAR COMPONENTS AFTER ADMINISTRATION OF THIAMINE PROPYLDISULFIDE-^<35>S

Yoshinori ITOKAWA

Article type: Article
1965Volume 32Issue 2 Pages 205-210
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_205

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The author investigated the fractional determination of thiamine esters in the various organs and accumulation of ^<35>S in the subcellular components of liver and heart after administration of TPD-^<35>S (inner) to rats. The ^<35>S in the heart mitochondrial fraction increased remarkably after administration of TPD-^<35>S (inner) and replacement ratio of thiamine in mitochondrial fraction after administration of TPD-^<35>S (inner) was higher than in the case of thiamine-^<35>S.

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STUDIES ON THE NUTRITIONAL VALUE OF ALLIUM PLANTS : (XVVIII) THE AFFINITY OF THIAMINE PROPYLDISULFIDE-^<35>S AND THIAMINE-^<35>S TO THE NEURAL TISSUES

Hiroyasu OTSKA

Article type: Article
1965Volume 32Issue 2 Pages 211-221
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_211

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The distributions of ^<35>S in various neural tissues, such as cerebrum, cerebellum, brain stem, spinal cord and ischiatic nerve, were determined after an intravenous injection of thiamine propyldisulfide (TPD)-^<35>S (inner or outer) or thiamine-^<35>S in rabbits. It was clarified that thiamine in neural tissues was turned over by injected radioactive thiamine very slowly. The retentions of ^<35>S of TPD-^<35>S (inner) or thiamine-^<35>S in the neural tissues were longer than that of ^<35>S of TPD-^<35>S (outer).

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EPOXYCAROTENOIDS : (VIII) POLLEN CAROTENOIDS OF LILIUM LONGIFLORUM THUNB. AND OF ITS CULTIVATED HYBRID

Kiyoshi TSUKIDA, Keiko IKEUCHI

Article type: Article
1965Volume 32Issue 2 Pages 222-226
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_222

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Extraction of fresh pollens of the titile plants, followed by repeated column chromatography (the adsorbent : lime, the developer : 1,8 or 10% acetone in n-hexane) gave 12 carotenoid pigments, namely 2 cis-mutatoxanthin esters (mainly as palmitate), 3 cis-zeaxanthin esters, 4 cis-antheraxanthin esters, a cis-antheraxanthin, and 2 unidentified carotenoids. Main constituents, cis-antheraxanthin ester-IV and -I, both have peripheral monocis structures of which 9 (or 9') - and 9' (or 9)-monocis configurations are most probable respectively. Cis-antheraxanthin esters were contained to the amount of 91.7-94 % of the total carotenoids, whereas all-trans compounds of the above carotenoids, α-, β-carotene, violaxanthin, capsanthin, and capsorubin were not found. Spectral data and estimated relative amounts of individual carotenoids were tabulated.

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EPOXYCAROTENOIDS : (IX) REACTION OF EPOXYCAROTENOIDS WITH CONCENTRATED HYDROCHLORIC ACID IN CHLOROFORM SOLUTION

Kiyoshi TSUKIDA, Miya YOKOTA

Article type: Article
1965Volume 32Issue 2 Pages 227-231
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_227

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Chloroform-dioxane (1 : 1)-conc. HCl method was extended to the determination of epoxycarotenoids and total amount of β-carotene monoepoxides or diepoxides was determined photometrically by this method (absorbance was measured at 630mμ for monoepoxides and at 700mμ for diepoxides). Green substance derived from chloroform solution of β-carotene-5,6-monoepoxide and conc. HCl was treated with water to give the mixture of yellow-orange pigments. Column chromatography of this mixture over lime revealed the presence of 41 chromatograms (13 mains and 28 minors) and the structure of several main components were assigned as all-trans- or monocis- compound of retro-bisdehydromutatochromes (I), retro-dehydromutatochromes (II), dehydromutatochrome (III), mutatochrome (V) and (IV). Small amounts of cis-mutatochromes and keto-mutatochromes (?) were also detected. Reaction mechanism was discussed from spectral data.

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STUDIES ON DRUG DIABETES : (IV) ABNORMAL CARBOHYDRATE METABOLISM INDUCED BY NICOTINIC ACID

Ryuichi ISHIGAMI, Shigeru SHIOTANI, Akira YOSHIDA, Toshinobu KAWATA, H ...

Article type: Article
1965Volume 32Issue 2 Pages 232-239
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_232

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The Occurrence of abnormal carbohydrate metabolism have been reported recently in patients administered with nicotinic acid in large doses for prolonged duration as a decholesterolic agent. We have studied on carbohydrate metabolism in patients with various diseases administered with large doses of nicotinic acid for a long time. Aggravation of diabetes mellitus and relatively frequent incidence of abnormal carbohydrate metabolism were observed in patients with normal carbohydrate metabolism. Occurrence of abnormality in liver function was also noted. Therefore, frequent examinations for carbohydrate metabolism and for liver function should be performed when the patients are administered with large doses of nicotinic acid for prolonged duration.

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ARIBOFLAVINOSIS CAUSED BY THE ADMINISTRATION OF CHLORTETRACYCLINE

Kunio YAGI, Yoshiko YAMAMOTO, Misao KOBAYASHI

Article type: Article
1965Volume 32Issue 2 Pages 240-244
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_240

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Ariboflavinosis caused by the administration of chlortetracycline was studied by using albino rats. Body weight gain and flavin content of the liver and kidney of the animals were measured with 7 groups of animals : (1) riboflavin-deficient diet, (2) 10 μg of riboflavin, (3) riboflavin-deficient diet plus chlortetracycline 5 mg per day for a rat, (4) riboflavin 2 μg plus chlortetracycline 5 mg per day for a rat, (5) riboflavin 2 μg plus chlortetracycline 10 mg per day for a rat, (6) riboflavin 5 μg plus chlortetracycline 10mg per day for a rat, and (7) riboflavin 10 μg plus chlortetracycline 10 mg per day for a rat. The results showed that chlortetracycline promotes the appearance of ariboflavinosis. As to the cause of ariboflavinosis, riboflavin and chlortetracycline act in competition with each other. This may be explained, at least partly, by the previously reported fact that chlortetracycline forms a complex with riboflavin and inhibits flavin enzyme in competition with the coenzyme FAD as studied by using D-amino acid oxidase.

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THE ANTAGONISTIC ACTION OF HOMOPANTOTHENIC ACID AGAINST PANTOTHENIC ACID

Fumio MATSUZAKI

Article type: Article
1965Volume 32Issue 2 Pages 245-259
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_245

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The action of homopantothenic acid, HOCH_2C(CH_3)_2CHOHCONH(CH_2)_3COOH, a derivative of γ-aminobutyric acid, and its hydroxy-forms was examined using lactobacilli and chick. These compounds showed a pronounced competitive antagonistic action for Lactobacillus arabinosus 17-5 and Leuconostoc mesenteroides P-60. When the 50% growth inhibition of homopantothenic acid was used as the index, an inhibition ratio of 150 was obtained. In the chick given 1mg/kg a day of pantothenic acid, oral administration of more than 2g/kg of homopantothenic acid induced pantothenic acid deficiency and reduction of liver CoA. These changes could be reversed by administration of pantothenic acid. This antagonistic effct of homopantothenic acid against pantothenic acid would be attributed to an inhibitory action in the pathway of biosynthesis from pantothenic acid to CoA.

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STUDIES ON THIAMINE DISULFIDE DERIVATIVES : (I) SYNTHESES OF THIAMINE DISULFIDE DERIVATIVES

Toshio AMMO, Takeshi SAKAI, Eiichi FUJIHIRA, Takao AIZAWA

Article type: Article
1965Volume 32Issue 2 Pages 260-264
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_260

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A number of derivatives of O-acyl- and O-carboalkoxythiamine disulfide as shown in Table 1 and 2 were synthesized for the purpose of studying how the carbon numbers and configuration of branched chain of O-substituents influence upon the intestinal absorbability and biological efficiency of these derivatives.

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STUDIES ON THIAMINE DISULFIDE DERIVATIVES : (II) BIOLOGICAL ACTIVITIES OF THIAMINE DISULFIDE DERIVATIVES

Toshio AMMO, Takeshi SAKAI, Takao AIZAWA, Eiichi FUJIHIRA, Akira NAGAN ...

Article type: Article
1965Volume 32Issue 2 Pages 265-268
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_265

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In studies on biological activity of the thiamine disulfide derivatives previously prepared, several characteristic properties were proved in O-acyl ones, of which O-isobutyrylthiamine disulfide maintaines higher blood total thiamine level for a long time in rabbits by oral administration than other analogues and is fairly effective in either curative or prophylactic potency on the rat given the thiamine dificient diet.

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STUDIES ON THE ABSORPTION AND EXCRETION OF THAMINE PROPYLDISULFIDE : (VII) AUTORADIOGRAPHIC STUDIES OF INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE-^<14>C

Kazuo ASO, Shozo KONDO, Teruo SHIOMI, Katsu TAKENOUCHI

Article type: Article
1965Volume 32Issue 2 Pages 269-277
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_269

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By the autoradiography of intestinal wall after the introduction of thiamin-^<14>C hydrochloride or thiamine propyldisulfide-^<14>C into the ligated intestinal cannal, it was revealed the following facts. In an early stage of absorption, thiamine-^<14>C accumulated on the surface of villi of intestinal mucosa. Then it appeared at the basal layer and lymphatic space. ^<14>C accumulated in the deep layer of mucosa or just above the mucosa of intestinal wall 15〜20 minutes after the introduction. Similar results were obtained when thiamine hydrochloride or thiamine propyldisulfide is administered.

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Article type: Article
1965Volume 32Issue 2 Pages 278-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_278_1

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Article type: Article
1965Volume 32Issue 2 Pages 278-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_278_2

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Article type: Article
1965Volume 32Issue 2 Pages 278-279
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_278_3

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Article type: Article
1965Volume 32Issue 2 Pages 279-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_279_1

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Article type: Article
1965Volume 32Issue 2 Pages 279-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_279_2

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Article type: Article
1965Volume 32Issue 2 Pages 279-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_279_3

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Article type: Article
1965Volume 32Issue 2 Pages 280-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_280_1

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Article type: Article
1965Volume 32Issue 2 Pages 280-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_280_2

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Article type: Article
1965Volume 32Issue 2 Pages 280-281
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_280_3

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Article type: Article
1965Volume 32Issue 2 Pages 281-282
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_281

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1965Volume 32Issue 2 Pages 283-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_283_1

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1965Volume 32Issue 2 Pages 283-284
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_283_2

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Article type: Article
1965Volume 32Issue 2 Pages 284-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_284_1

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Article type: Article
1965Volume 32Issue 2 Pages 284-285
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_284_2

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Article type: Article
1965Volume 32Issue 2 Pages 285-
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Article type: Article
1965Volume 32Issue 2 Pages 285-286
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_285_2

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Article type: Article
1965Volume 32Issue 2 Pages 286-
Published: August 25, 1965
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Article type: Article
1965Volume 32Issue 2 Pages 286-287
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_286_2

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Article type: Article
1965Volume 32Issue 2 Pages 287-
Published: August 25, 1965
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Article type: Article
1965Volume 32Issue 2 Pages 287-288
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_287_2

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Article type: Article
1965Volume 32Issue 2 Pages 288-
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Article type: Article
1965Volume 32Issue 2 Pages 288-289
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_288_2

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Article type: Article
1965Volume 32Issue 2 Pages 289-
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[title in Japanese]

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Article type: Article
1965Volume 32Issue 2 Pages 289-
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DOIhttps://doi.org/10.20632/vso.32.2_289_2

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Article type: Article
1965Volume 32Issue 2 Pages 289-290
Published: August 25, 1965
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Article type: Article
1965Volume 32Issue 2 Pages 290-
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Article type: Article
1965Volume 32Issue 2 Pages 290-291
Published: August 25, 1965
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Article type: Article
1965Volume 32Issue 2 Pages 291-
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[title in Japanese]

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Article type: Article
1965Volume 32Issue 2 Pages 291-292
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_291_2

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[title in Japanese]

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Article type: Article
1965Volume 32Issue 2 Pages 292-
Published: August 25, 1965
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DOIhttps://doi.org/10.20632/vso.32.2_292_1

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[title in Japanese]

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Article type: Article
1965Volume 32Issue 2 Pages 292-
Published: August 25, 1965
Released on J-STAGE: February 09, 2018

DOIhttps://doi.org/10.20632/vso.32.2_292_2

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