Abstract
One of the authors (Itokawa) had reported the distribution of ^<35>S in the blood after administration of TPD-^<35>S (inner) and TPD-^<35>S (outer) in the previous paper. In the present paper, the authors investigated the distribution and retention of ^<35>S in various organs in the body. After injection of TPD-^<35>S (outer), ^<35>S was found in the largest quantity in the kidney, followed in order by the blood, lung and liver. Distribution of the ^<35>S from TPD-^<35>S (inner), on the other hand, was most marked in the liver, followed by the spleen, small intestine, kidney and blood. After oral administration, the ^<35>S from TPD-^<35>S (inner) was found in the small intestine and liver in large quantities, while the increase in ^<35>S from TPD-^<35>S (outer) was not marked. The ^<35>S of TPD-^<35>S (inner) penetrated into the liver and heart at higher concentration and was retained for a longer time than the ^<35>S of TPD-^<35>S (outer>. In the blood and intestinal tract, however, this relation was reversed.
