抄録
Large dosage of dietary myoinositol seemed to be inhibitory on the growth of young rats (about 20 days after birth) ; it was found that the body weight increase of young animals fed on a large excess of myoinositol (1g/kg/day) was significantly lower than those fed on the standard diet containing myoinositol (10 mg/kg/day), and even lower than those fed on the inositol deficient diet. However, such an inhibitory action was not seen in the case of older rats (3-4 months after birth) fed on large amounts of myoinositol (5g/kg/day). Concerning these findings, the changes in the pattern of lipids in the liver were investigated, and it was found that the larger the dosage of dietary myoinositol, the larger the P/N ratio of hepatic lipids, although there was no significant changes in the relative amounts of the total lipids and cholesterol in the liver. The result suggested the possibility that the dietary myoinositol had some effects on phospholipid metabolism in the liver, in particular of the young rats. Relating to such changes in liver lipid patterns, discussions were made on the mechanism of the growth-depressing action of myoinositol when it was supplied to the young animals in a large excess amount.
