ビタミンK欠乏の雌性性機能におよぼす影響にかんする実験的研究 : (I)ビタミンK欠乏症の惹起法およびビタミンK欠乏の妊娠機能におよぼす影響

抄録

Adult female rats were used to study the feeding technique to produce vitamin K deficiency syndrome and its influence upon the general condition, sexual cycle and pregnancy of the animal. In some of the rats fed on vitamin K-free diet, equipped with the coprophagy preventing tail cup and in all of the animals fed on the diet with 0.05% of sulfaquinoxaline, it was observed hypothrombinemia and hemorrhage of some degree. The sexual cycle and the potency for conception of the animal were tolerably maintained even in a vitamin K deficient condition, but the growth was impeded under the deficiency and the pregnant animal was more susceptible than non-pregnant one to the deficiency. About in a half of the pregnant animals fed on vitamin K-free diet, pregnancy could be kept on to the term by simultaneous administration of estrogen and progesterone, although the fetal development was seriously arrested. The administration of progesterone alone could not maintain the pregnancy to the term.