Abstract
The effect of vitamin K_1 on the endocrine activity was studied in the Wistar-strain rats weighed 120-160g by measuring of urinary 17-KS and the following results were obtained. An increase of the excretion of 17-KS was observed in the rat administered with 100 μg of vitamin K_1 daily for 20 days. The excretion of 17-KS increased temporarily by the administration of 1 mg and 10 mg of vitamin K_1 and, then, it decreased by the continuous administration. These findings suggest that a small dose of vitamin K_1 canses an of increase the activities of adrenal cortex and ovaries, while a large dose induces a transient hyperfunction of the adrenal cortex and ovaries and, then, gradual decrease occurs.
