Abstract
The effect of vitamin D on the urinary excretion of 17-KS in rat was studied. Urinary 17-KS was determined by the modified method of Drekter, twice a week. Normal and castrated mature female rats weighed 120-160g were injected intramuscularly with vitamin D for 20 days. No significant change of 17-KS excretion was found in the groups which were administered daily 10 or 100 I.U. of vitamin D, while a tendency of gradual decrease was observed in the animals administered with 1,000 I.U. of vitamin D daily. These findings suggest that no significant change of function of adrenal cortex and ovaries is induced by the administration of a small amount of vitamin D and, on the other hand, a large dose of vitamin D suppresses their functions.
