抄録
In the thiamine-deficient rats, body weight and appetite dcereased gradually from the second week of thiamine deficiency. The growth stopped when their body weight reached to 80-90g. In the 4th week anorexia and the body weight decrease developed rapidly. Most of rats lost their vitality and revealed paralytic gastrointestinal symptom. But when thiamine in dose of 40μg was given subcutaneously in the end stage of thiamine deficiency, the rats caused an increase in appetite and body weight on the next day and were cured the paralytic symptom in a few days. They gained 5-10g of weight daily but stopped growing after 3 days and they lost their body weight and became enervated again. After the effect of thiamine lasted for 12-14 days, they died of thiamine deficiency. When 200μg of thiamine was given by subcutaneous injection to thiamine-deficient rats in the 4th week, they regained vitality after 24 hours and their body weight and appetite increased. They gained 8-13g of weight daily and kept growing evenly to 80-90g and stopped growing after 10 days. At the 25 days after injection, deficient syndrome appeared completely, and the animal died in the 4th or 5th week after injection. Effect of thiamine injection in dose of 200μg lasted for 25 days. These results support the view that the excessive administration is apposite for the treatment of thiamin-deficient diseases. In the second experiments, it was found that the growth curves were similar, even if deficiency and recovery by thiamine administration of 200μg were repeated several times. But in case of deficiency and recovery by 50μg thiamine was repeated several times, the rats could not regained their vitality and at last they died in spite of thiamine administration. These results suggest that excessive administration of thiamine is more effective than small administration.
