Abstract
The intraperitoneal injection of homopantothenic acid (HOPA) was effective to reduce the excitation, tremor and death rate of rats induced by the cutaneous application of dichlorodiphenylpentachloroethane. The simultaneous administration of HOPA and pyridoxal phosphate was more effective than the widely recommended drug, phenebarbital. HOPA showed the remarkable inhibition of spastic convulsion and immediate death-rigor in cutaneous pentachlorophenol poisoning in rats.
