Abstract
The curative effects of orally given hydroxocobalamin were examined in 25 diabetic outpatients with persistent manifestations of subjective signs of diabetic neuropathy and /or decreased motor nerve conduction velocity (MNCV) of ulnar nerve. In most of the cases, 1500μg of hydroxocobalamin was given as a daily dosis for 14-127 days. In few cases, 3000μg was given every day. An improvement of subjective signs of nervous disorders and changes in tendon reflex, calf tenderness and MNCV were used as indicators of the curative effects. Curative effects of hydroxocobalamin were more remarkable in 4-5th decade-diabetics with shorter duration of the disease and also in mild diabetics with good control of the disease. The drug was less effective in cases with advanced diabetic vascular complications. A significant elevation of MNCV was observed 11 of the 25 cases after the hydroxocabalamin therapy. In most of the cases, an amelioration or a disappearance of neuralgic pain, of paresthesia and of the symptoms of autonomic nervous dysfunctions was seen during the treatment.
