抄録
The antithiamine actions of aminothiamine were investigated using several biological systems. The growth of L.fermenti 36 which requires thiamine for its growth was inhibited by aminothiamine. The inhibition of aminothiamine was recovered competitively by thiamine and the inhibition index was 450-470. The uptake of thiamine in resting cells of baker's yeast and L. fermenti 36 was also inhibited competitively by aminothiamine as well as yeast thiamine kinase. As one of the sites of antithiamine action the competition between thiamine and aminothiamine on the cell membrane in the active transport of thiamine was discussed.
