眼内圧上昇の眼組織ビタミンB_1含有量に及ぼす影響

抄録

The intra-ocular pressure of the rabbits was maintained for one hour at 150,140,130,110,90,70,and 56mmHg with a leveling manometer and the concentration of total thiamine, free thiamine and thiamine phosphate in the retina and the optic nerve was measured. The concentration of total thiamine and its phosphate in the retina decreased with the elevation of the intra-ocular pressure over 90mmHg. When the intra-ocular pressure persisted at 150mmHg for 2.5 hours, contents of thiamine phosphate in the retina decreased further than when the elevation persisted for one hour. When the duration of the elevation of the intra-ocular pressure at 150mmHg was limited to one hour, the decrease of the total thiamine and its phosphate in the retina proved to be reversible by the normalizing of the intra-ocular pressure. But when the elevation of the intra-ocular pressure at 150mmHg persisted for 2.5 hours, decreased contents of the total thiamine and its phosphate were not reversed even when the intra-ocular pressure returned to normal. The intra-ocular pressure was maintained at 30,56,and 150mmHg with a manometer. One hour after an intravenous injection of thiamine propyldisulfide 10mg per kg, the concentration of total thiamine, free thiamine and thiamine phosphate in the ocular tissues was measured. The concentration of all types of thiamine in the retina and the choroid almost decreased when the intra-ocular pressure became higher than 56mmHg, as compared with the concentration in these tissues of normal intra-ocular pressure one hour after an intravenous injection of thiamine propyldisulfide 10mg per kg, and these decreases became greater with the elevation of the intra-ocular pressure.