Abstract
The author studied the influence of vitamin K_1 administration on the growth, sexual cycle and pregnancy of the Wistar strain female rats and made research for the morphological changes of the anterior pituitary glands, ovaries and uteri of the animals following K_1 administration. Relative small dosis of K_1 (100μg×20 days) stimulated the growth and sexual cycle in slight degree. And in the anterior pituitary glands, an increase of the acidophilic cells was observed. Hypertrophy or hyperplasia of the adrenal cortex, slight increase of ovarian follicles and corpus luteum, hypertrophy of the endometrium and the myometrium were also noted. The same dosis administration of K_1 during pregnancy gave a favorable influence on the growth of both fetus and new-born to some extent. Parallel to the increase of the dosis (1-10mg×20 days) a slight supression of the growth and the sexual cycle of the animals. Increase of basophilic β cells with a certain degree of hypertrophy, and simultaneous decrease of acidophilic cells in the anterior pituitary glands, atrophy of the deeper layer of adrenal cortex, decrease of ovarian follicles and corpus luteum, and atrophy of the uteri became evident. Tendency for premature birth was observed after large dose administration.
