STUDIES ON THIAMINE DISULFIDE DERIVATIVES : (V) REVERTION OF THIAMINE DISULFIDE DERIVATIVES TO THIAMINE BY THE HOMOGENATES OF SEVERAL RAT ORGANS

Abstract

The stability of various O-acylthiamine disulfide derivatives in the homogenates of several rat organs, i.e. intestinal mucous membrane, liver, blood corpuscle and blood serum, was investigated. All of homogenates proved to have the both abilities for release of acyl group and cleavage of S-S linkage, while the both potencies did not run parallel. The deacylation was most marked in intestinal mucous membrane, liver and serum, while the cleavage of S-S was the strongest in blood corpuscle. The deacylation was more rapid in the compound having higher carbon atoms and was more easy in straight chain than branched one.