ANTI-INFLAMMATORY EFFECT OF THIAMINE DERIVATIVES

Abstract

Intraperitoneal1y administered TTFD (thiamine tetrahydrofurfuryldisulfide) and TPD (thiamine propyldisulfide) showed a strong inhibitory effect on carrageenin induced rat paw edema, while the strong anti-inflammatory effect was not observed by oral administration of TTFD and TPD. On the other hand, BTMP (S-benzoylthiamine monophosphate), DCET (O, S-dicarbethoxythiamine) and thiamine hydrochloride hardly inhibited carrageenin edema even with intraperitoneal route. None of TTFD, BTMP, DCET and thiamine hydrochloride showed a significant suppressive effect on ultraviolet erythema on guinea pigs and croton oil granuloma pouch in rats.