ビタミンB_1誘導体の抗炎症作用 : 3種の抗炎症効果検討法の相関を含めて
1967 年 36 巻 4 号 p. 305-310
詳細
1967 年 36 巻 4 号 p. 305-310
Intraperitoneal1y administered TTFD (thiamine tetrahydrofurfuryldisulfide) and TPD (thiamine propyldisulfide) showed a strong inhibitory effect on carrageenin induced rat paw edema, while the strong anti-inflammatory effect was not observed by oral administration of TTFD and TPD. On the other hand, BTMP (S-benzoylthiamine monophosphate), DCET (O, S-dicarbethoxythiamine) and thiamine hydrochloride hardly inhibited carrageenin edema even with intraperitoneal route. None of TTFD, BTMP, DCET and thiamine hydrochloride showed a significant suppressive effect on ultraviolet erythema on guinea pigs and croton oil granuloma pouch in rats.
