抄録
The nicotinamide coenzyme contents in the livers estimated fluorometrically after administratio of L-tryptophan intra-peritoneally were found to be about the same as normal in alloxan-diabetic rats, although the urinary excretion of N'-methylnicotinamide in alloxan-diabetic rats was about one-half of that in normal rats. In order to know the metabolic rate of NAD synthesized in the alloxan-diabetic rat liver, the increase of NAD content in the liver and the urinary excretion of N'-methylnicotinamide after administration of niacin were compared between both rats. The each values estimated had no difference between normal and alloxan-diabetic rats. The liver NADase activity was also same in both rats. The mechanism maintaining NAD in the diabetic rat liver at normal level was discussed.
