ビタミンB_6の血液凝固および線維素溶解作用に及ぼす影響にかんする実験的ならびに臨床的研究

抄録

The effects of vitamin B_6 on blood coagulation and fibrinolytic activity were investigated. In vivo, PAL-P prolonged whole blood clotting time and plasma recalcification time and activated fibrinolysis, while PAM-P or PIN showed no such effects, except that PAM-P slightly prolonged whole blood clotting time. Also in vitro, PAL-P prolonged plasma recalcification time and had the antithrombin activity, inhibiting the thrombin fibrinogen reaction, while PAL, PAM-P, PAM, PIN-P and PIN did not show such effects. Cocarboxylase and ATP did not prolong plasma recalcification time in vitro. PAL-P inhibited the hydrolysis of p-toluene sulfonylarginine methyl ester by thrombin and increased plasma antithrombin activity. Using thromboelastogram of citrated plasma, it was observed that PAL-P in low concentration increased the effect of ε-aminocaproic acid on the fibrinolytic system produced by streptokinase. These effects of PAL-P do not seem physiological ones of vitamin B_6,but pharmacological.