EFFECT OF TOXOHORMONE ON RAT LIVER RIBOFLAVIN

Abstract

It is well known that liver catalase activity of tumor-bearing animals is significantly lower than that of normal animals. Nakahara, et al. suggested that certain toxic substances might be produced in tumor tissue which caused decrease of liver catalase activity of tumor-bearing animal, and it was called "toxohormone." We reported before that the riboflavin content of tumor-bearing rat liver decreased significantly after the transplantation of tumor. In this report, the author studied the effect of toxohormone on rats liver riboflavin. It was clearly shown that toxohormone cause a decrease of riboflavin, especially in mitochondrial fraction. It was also discussed the effect of toxohormone on flavokinase and FAD-pyrophos-phorylase.