Abstract
O-Nicotinylthiamine disulfide (I) was synthesized by acylation of thiamine disulfide (II) with nicotinylchloride. It was also prepared either by direct reaction of II with nicotinic acid and ethylchloroformate, benzene sulfonylchloride. Its chemical and physical properties were reported. The compound is white, odorless and hygroscopic. The ultraviolet spectrum of the compound has its absorption maximum at 255mμ in acidic solution, which varies depending on pH of the solution. The infrared spectrum shows specific absorption band at 1720cm^<-1> (ν^<C=O>) and 1280cm^<-1> (ν^<C_O_C>). The compound is found to be stable in powdered form and is also stable in acidic solution than in neutral or alkaline solution.
