Investigations were carried out on the pharmacological effects of O-nicotinylthiamine disulfide (NTDS). The doses for mouse were 12.2 g/kg in oral administration and 0.32g/kg in intravenous injection. On the cardio-vascular system, the blood pressure and respiration, NTDS acted similiarly to thiamine. NTDS had little effect on the isolated intestine of rabbit.
