ビタミンDの雌性性機能におよぼす影響にかんする実験的研究

抄録

To investigate the influences of vitamin D on female sexual function, Wistar strain rats were fed on vitamin D-free diet or were administered with vitamin D. (1) By feeding on vitamin D-free diet the sexual cycle of the rats were put out of order. In the adenohypophysis, α-cells decreased throughout the period of the experiment and δ-cells increased in just the early period. Atrophy of the adrenal cortex and the ovaries were seen after the middle stage of the period. Uterine atrophy began in early period. (2) In proportion of the dosis of vitamin D_2,both α- and β-cells were increased in the adenohypophysis, and functional acce leration of the adrenal cortex and ovaries were observed with uterine hypertrophy. Administration of vitamin D_2 was seemed to inhibit the castration changes of the adenohypophysis to some extent. (3) Vitamin D-deficiency caused marked interference to fertility and injury to fetal development owing to early atrophy of the syncytial trophoblast in the placental labyrinth in pregnant rats. After all, vitamin D deficiency brings on the sexual disorder to the female.