Abstract
Effect of autonomic blocking agent on the thiamine distribution in the salivary gland of dog was investigated by means of thiochrome method. Total and free thiamines in the parotid and submandibular gland were found to be decreased at 30 minutes after atropine sulfate injection subcutaneously and then they were restored to normal value gradually, whereas it was found to increase remarkably at 30 minutes after pilocarpin hydrochloride injection. From these results the authors suggest that there are close correlations between salivary secretion function and thiamine metabolism and that thiamine metabolism is promoted remarkably when salivary gland was hyperfunctional state, on the contrary, decrease of salivary secretion was induced the inhibition of thiamine turnover in the gland.
