Abstract
Induction of fatty liver in rats by feeding on diets containing 1.5% orotic acid for 7 days, was accompanied with the increase in the lipid TBA value and with the decrease in the lipid phosphorus concentration. However, fat accumulation was prevented by injecting 30mg of myoinositol or choline subcutaneously every day during the experimental period . The prevention was found to be about 30-50% with myoinositol and 60-80% with choline. However, the effects of choline and myoinositol were not additive; the effect due to the injection of both choline and myoinositol was rather close to the effect of myoinositol alone. The increase in TBA value and the decrease in lipid phosphorus concentration were also found to be prevented by injecting these lipotropic factors.
