抄録
In the previous paper, it was reported that the effect of B_2-But_2^<*2)> had been investigated on rats. Afterwards, the present authors have studied the biological effects of synthetic riboflavin-dinicotinates on rats. Riboflavin-2', 3'-dinicotinate, riboflavin-4', 5'-dinicotinate and 3-N-benzoylriboflavin, that were newly synthesized by the Toa-Eiyo Chemical Industries Co. were used. Using riboflavin-deficient male rats of Wistar strain as test animals weighing 50- 60g, the prophylactic and curative experiments were carried out by oral administration with 30μg of each test compound as FR^<*6> / day / rat. The growth curves were recorded throughout the experimen's, and at the end of the experiments, animals were killed by decaptation and the total riboflavin contents of various tissues were estimated by the Yagi's fluorometric method, and the total nicotinic acid contents in the liver of the B_2-Nic^<*9> given animals were messured by the ordinary microbiological assay with L. ar abinosus. The results are briefly summarized as follows. The growth rates showed rather lower than that of the FR group, and the total nicotinic acid contents in the liver of B_2-Nic given animals was found to be remarkably increased.
