Abstract
The influence of vitamin E on the ADP induced platelet aggregation was studied. Platelet rich plasma (PRP) was prepared from the blood obtained from normal person with 3.8% of trisodium-citrate as anticoagulant. α-Tocopherylacetate was added with the concentration of 0.1,0.2 and 0.5 mg/ml PRP, 2 hours prior to the addition of ADP (1 μg/ml PRP), and the same amount of solvents contained in 0.1,0.2 and 0.5 mg of tocopherol, respectively to 1 ml of PRP. 0.15,0.3 mg of α-tocopherylacetophosphate were added to PRP 1 ml, respectively, just prior to the addition of ADP. The grade and duration of platelet aggreagtion was measured with Shimadzu-Bauschlomb Spectrophotometer at 610 mμ. 0.5 mg of α-tocopherylacetate, 0.15 mg and 0.3 mg of α-tocopherylacetophosphate seemed evidently to inhibit the ADP induced platelet aggregation, and rather promototed its effect in every other cases.
