Abstract
The growth of E. coli B was inhibited by some analogues of nicotinic acid (NiA) or nicotinamide (NAA) in the following order : pyridazine-3-carboxamide (Pyd-3-CAA)> 6-aminonicotinamide (ANNA)> pyridazine-3-carboxylic acid (Pyd-3-CA). Pyd-3-CAA was found to be the most potent inhibitor for E. coli B.. The inhibition was recovered by NAA slightly better than NiA, and by quinolinic acid (QA) in higher concentrations. However, Pyd-C-3-AA did not exhibit any inhibitory effect to L. arabinosus 17-5 and Leuc. mesenteroides ATCC 9135. Another inhibitor of amido type, ANAA, also didnot inhibit the growth of the both bacteria. On the contrast, Pyd-3-CA inhibited competitively the growth of the Leuc. mesenteroides ATCC 9135 (inhibition index, about 760) as well as the L. arabinosus 17-5,the latter was reported previously.
