Abstract
The diazepine compound (I) of thiamine, when heated in its alkaline solution of pH 8〜9 (NaOH, bicarbonate or borate buffer), was partly transformed to desthiothiamine (II), while (II) was also partly converted to (I) on heating in its non-aqueous solution, such as pyridine, ethylate, or formic acid. The compounds (I) and (II), when incubated in 2% NaOH solution for hours, were easily converted into the corresponding desformyl compounds (III) and (IV) with formation of formic acid. The fomation of the furothiazine compound from these compounds (I), (II), (III) and (IV), in the reaction with γ-mercapto-γ-acetopropylalcohol (V) in alkaline solution (pH 12.5), was demonstrated by means of paper chromatography and the higher yield was observed in the reaction of the desformyl compound (III) or (IV) with (V) than that of (I) or (II).
