Abstract
Various doses of predonisolone of 2,8,and 40mg/kg body weight/day and ACTH of 25 I.U./kg body weight/day for 1,3,10 and 20 days were injected into young albino rats. 1) Hepatic concentration of CoA increased from 3 to 10 days after the injection of 8 or 40mg/kg body weight/day of predonisolone and 3 days after the injection of ACTH. 2) Hepatic concentration of CoA decreased 20 days after the injection of 8 or 40mg/kg body weight/day of predonisolone. 3) Hepatic concentration of total pantothenic acid increased from 1,3 and 10 days after the injection of 8mg/kg body weight/day and 3 days after the injection of 40mg/kg body weight/day of prdonisolone. 4) No remarkable changes in hepatic concentration of CoA precursors and free pantothenic acid in these groups were found.
