Abstract
Hepatic concentration of CoA, its precursors and pantothenic acid in adrenalectomized rats and of those treated with predonisolone 8mg/kg body weight/day for 3 days by intracutaneous injection were studied. 1) Hepatic concentration of CoA and pantothenic acid decreased 4 days after adrenalectomy. 2) Decreased hepatic concentrations of CoA and total pantothenic acid in adrenalectomized rats were recovered by the treatment of predonisolone in the above-mentioned way. 3) Even in shamoperation, however, hepatic concentration of CoA and total pantothenic acid decreased on the level of 66% of the control group. 4) No remarkable changes in hepatic concentration of CoA precursors and free pantothenic acid in each group were shown.
