Abstract
Hepatic concentration of CoA and pantothenic acid in adrenalectomized rat after injection of CoA 0.9 μmoles for 4 days, Ca-pantothenate 0.9 μmoles or 4.5 μmoles for 4 days and predonisolone 8mg/kg body weight/day for 3 days intracutaneously were observed, respectively. 1) The reduction of body weight in the CoA administered group was slighter than in the pantothenate injected group and its activity was better. 2) Hepatic concentration of CoA and total pantothenic acid decreased most remarkably in the pantothenate 0.9 μmoles administered group. 3) Hepatic concentration of CoA and total pantothenic acid increased in the CoA administered group. 4) No differences in hepatic CoA and total pantothenic acid content between CoA and predonisolone administered groups and also between pantothenate 0.9 μmoles and predonisolone 4.5 μmoles administered group were observed.
