抄録
Albino rats were fed on a pantothenic acid-deficient diet, supplemented in their diet with the antimetabolite, ω-methyl-pantothenic acid. After three months the rats on pantothenic acid-deficient diet were shown to be in appearance of fatty livers. It was observed that significant lowering of the relative ratios of stearic to palmitic acid and arachidonic to linoleic acid on the fatty acid composition of the liver lipids from pantothenic acid deficient animals. This fact may propose an hypothesis that pantothenic acid-deficiency reduce an activity of the metabolic process involved chain-elongation of fatty acid. A column chromatographic analysis on the liver lipids showed that the relative portion of phospholipid fraction was significantly lower in deficient animals than in the control animals. The determination of the fatty acid composition in these fractions suggested that the patterns of fatty acid in liver lipids were affected remarkably with the relative portions of phospholipids contained in their liver lipids.
