抄録
Thiamine disulfide monobenzoate (TDSMB) (II), a new derivative of thiamine, was prepared by the benzoylation of TDS (I) with equimolar benzoylchloride or sodium benzoylthiosulfate, followed by silicagel column chromatography. By recrystallizing from a mixture of benzene-ethanol, (II) was obtained as colorless scales consisting of C_<31>H_<38>N_8O_5S_2・1/2C_6H_6・H_2O and decomposed at 147-149°. The structure of (II) was confirmed by UV, IR, NMR spectra, elemental analysis and determination of benzoic acid. By treating (II) with alumina in CHCl_3,the partial disproportionation to (I) and BTDS (III) was observed by thin layer chromatography.
