Abstract
In order to clarify the relationship between thiamine and serotonin in animal bodies, tissue serotonin and thiamine levels in the thiamine deficient and the thiamine treated rats were determined. Following thiamine administration (10mg/kg) tissue serotonin levels increased in proportion to the increase in thiamine levels. Contrastly, serotonin levels in liver, stomach and duodenum were lowered and the brain serotonin level was increased in the thiamine deficient rats. Utilizing labeled 5HTP a precursor of serotonin for experiments, it was demonstrated that the uptake of 5HTP into tissues decreased markedly in thiamine deficient rats.
