抄録
Metabolism of ascorbic acid (AsA) and dehydroascorbic acid (DAsA) was studied in healthy six male and eleven female subjects on oral administration of 600mg each of AsA or DAsA. The levels of AsA and total AsA in blood were maximum at the 4th hour after AsA administration, but at the 2nd hour after DAsA administration. Of the vitamin C appearing in blood, AsA form was about 80% and DAsA form about 20%. At the maximum level, the amount of total AsA in the blood of whole body was estimated to be about 5% of the dose administered. The amount of the vitamin excreted in urine in 6 hours after loading was about 60 and 70% of the amount excreted in 24 hours, following administration of AsA and DAsA respectively. The amounts excreted in urine in 24 hours were about 30 and 40% of the dose administered in men and women respectively. Of the vitamin excreted, AsA form was about 90% and DAsA form about 10% in both sexes. No statistically significant difference between men and women, or between administration of AsA and DAsA was found in the amounts of the vitamin excreted in urine in 24 hours at a 5% level. The amount of the vitamin appearing in urine in 24 hours after oral intake of AsA is practically the same as that after intake of DAsA. The biological activity of AsA is considered to be the same as that of DAsA.
