抄録
Vitamin B_<12> was succinylated by reaction with succinic anhydride to yield O^<2'>-succinyl-, O^<5'>-succinyl-, and O^<2'>, O^<5'>-disuccinyl-cyanocobalamin. Biochemical studies on the three succinyl derivatives of vitamin B_<12> demonstrated that the α-ribose moiety of the nucleotide ligand is physiologically much important-especially for the binding of vitamin B_<12> to the apoprotein of coenzyme B_<12>-dependent diol dehydrase and for the uptake of this vitamin by Escherichia coli cells.
