Abstract
The effect of 2', 3'-di-o-nicotinoyl riboflavin-4'(5')-phosphate (DNRP) on the hypercholesterolemia in mice, rats, chicks and rabbits induces by feeding a cholesterol containing diet was studied. The following results were obtained. 1. The elevation of plasma cholesterol level in mice being fed a cholesterol containing diet was prevented in s.c. administration of 100 and 200 mg/kg/day of DNRP. 2. The elevation of plasma and liver cholesterol levels in rats was significantly prevented in s.c. administration of 60,120 and 120 mg/kg/day of DNRP, respectively. 3. The elevation of plasma cholesterol level in chicks was markedly accelerated at the first week, but not altered for the following 4 weeks by i.m. administration of 100 mg/kg/day of DNRP. The elevation of liver cholesterol level was also prevented in same dose of DNRP. 4. The elevation of plasma and liver cholesterol levels in rabbits was markedly reduced by s.c. or p.o. administration of 120 mg/kg/day of DNRP.
