抄録
To clarify the interrelationships of thiamine and mineral metabolism in magnesium and calcium deficient rats, male Wistar rats were divided into four groups. Group 1 was given a calcium and magnesium deficient diet, group 2 a calcium deficient and magnesium sufficient diet, group 3 a calcium sufficient and magnesium deficient diet and a calcium and magnesium sufficient diet was given to the group 4. These dietary regimens were performed for 4 weeks. Magnesium levels in telencephalon, brainstem, spinal cord and serum decreased in magnesium deficient groups (groups 1 and 3). However, no significant change was observed in magnesium levels in heart, liver, kidney and sciatic nerve among the groups. Calcium levels in telencephalon, brainstem, spinal cord and serum decreased in calcium deficient and magnesium sufficient group (group 2) and calcium levels in serum and kidney increased in calcium sufficient and magnesium deficient group (group 3). In calcium and magnesium deficient rats (group 1), calcium levels decreased in telencephalon, brainstem and spinal cord and increased in serum and kidney. Thiamine levels decreased in telencephalon, brainstem, spinal cord, sciatic nerve and heart in calcium deficient groups (groups 1 and 2) and on the other hand, in magnesium deficient groups (groups 1 and 3) thiamine levels decreased in liver, kidney and blood.
