Abstract
A method for partial synthesis of a cobalamin analogue containing 2-amino-2-methylpropanol (S102) in place of 1-amino-2-propanol, one of the strongest vitamin B_<12> antagonists, was investigated using cobyric acid and αribazolee phosphate, which had been obtained by hydrolyzing CN-B_<12> with HCl according to Bonnet's method as starting materials. The intermediates, cyc. α-ribazole phosphate and phosphate-diester of 2-amino-2-methylpropanol and α-ribazole, as well as the final product, S102, were identified by paper ionophoresis and UV・visible absorption spectra in comparison with those of the authentic preparations given by Prof. Friedrich.
