抄録
The administration of antivitamin B6 to mice is attended by intermittent running-fits. The cause of the onset of running-fit may be ascribed to the following successive events at some nerve terminals in mid-brain; the drop in pydidoxal phosphate level → in glutamic acid decarboxylase activity → in γ-aminobutyric acid level → in release of the amino acid. The intermittence (onset and cessation) of seizures appeares to tune with change in concentration of blood C0_2 which increases with the onset of seizures and converts an inactive γ-aminobutyric acid receptor into an active form.
