Percutaneous Absorption of Topically Applied Thiamin and Thiamin tetrahydrofurfuryl disulfide by Rats

Abstract

The absorption of topically applied thiamin and thiamin tetrahydrofurfuryl disulfide (TTFD) by the rat has been studied. Thiamin concentrations were high in blood and liver of 5% thiamin or 5% TTFD administered rat. After topical application of ointment for 2hrs, thiamin concentrations were significantly high in liver, spleen, kidney and blood of thiamin (5%) administrated rats, and in brain, liver, spleen, kidney, muscle and blood of the administered rats compared with those of control rats.