抄録
The nutritional and biological effeciency of nicotinuric acid as a substitute for nicotinic acid was investigated by using weanling rats fed with a nicotinic acid-free, tryptophan-limiting diet containing various amounts of nicotinuric acid. Judging from the growth response, food intake, food efficiency ratio, the levels of NAD activity in blood and liver, the level of total nicotinamide in the liver, and the urinary excretion of such nicotinamide metabolites as N^1-methylnicotinamide, N^1-methyl-2-pyridone-5-carboxamide, and N^1-methyl-4-pyridone-3-carboxamide, we conclude that nicotinuric acid was approximately 1/10 as active as nicotinic acid in weight basis and 1/7 in molar basis.
