抄録
Bioavailability of preparations of thiamin tetrahydrofurfryl disulfide (TTFD) was examined in 6 healthy male adult volunteers. 1. No significant difference was observed in the AUC and urinary excretion of vitamin B_1 in the daily 100 mg TTFD administration between single and twice divided dose. 2. C_<max> AUC and urinary excretion of vitamin B_1 were two fold higher at orally once administration of 100mg of TTFD as compared with those at the 50 mg administration. Those were in dose-dependent manner and did not differ between difference of the tablets. 3. There were no differences in its pharmacokinetic parameters between postprandial administration of 100 mg TTFD and the administration at fasting, but variables in blood levels with respect to the absorption seemed to be smaller in postprandial administration than in fasting administration.
