健常成人におけるビタミンB_1、B_6およびB_<12>主薬製剤経口服用時の血中動態
1997 年 71 巻 2 号 p. 75-80
詳細
1997 年 71 巻 2 号 p. 75-80
Pharmacokinetics and bioavailability of 2 multivitamin preparations including B_1, B_6, B_<12> and/or E were studied in human male volunteers. The same dosage of 100 mg thiamine tetrahydrofurfuryl disulfide (B_1) was included in both preparations. However, one preparation (Alinamin EX^<(R)>) included high amounts of 100 mg pyridoxine hydrochloride (B_6), 1500 μg hydroxocobalamin (B_<12>) and 100 mg d, l-α-tocopherol succinate (E). The other (Alinamin A50^<(R)>) included 10 mg riboflavin (B_2), 10 mg pyridoxine hydrochloride (B_6), 20 μg cyanocobalamin (B_<12>). the results were as follows : 1) B_1 : No difference was observed between AUC of both preparations. T_<max> tended faster in Alinamin EX^<(R)>. 2) B_6 : AUC by administration of Alinamin EX^<(R)> was 9 times larger than in Alinamin A50^<(R)>. 3) B_<12> : AUC by administration of Alinamin EX^<(R)> was 4 times larger than in Alinamin A50^<(R)>. 4) E : A significant increase in plasma was observed by administration of Alinamin EX^<(R)>. AUC represents the area under curve obtained from the blood drug concentration of the time course.
