ビタミン
Online ISSN : 2424-080X
Print ISSN : 0006-386X
嫌気条件下におけるチアミン・ピリミジン部の生合成経路 : コハク酸、グリシンのピリミジン部への取り込み
田中 敬子田鶴谷 惠子山田 和子熊岡 煕
著者情報
ジャーナル フリー

1999 年 73 巻 12 号 p. 721-726

詳細
抄録
There are different biosynthetic pathways of the pyrimidine moiety of thiamin in Saccharomyces cerevisiae and Escherichia coli under aerobic and anaerobic conditions. The precursors of the pyrimi dine under anaerobic conditions have not been established. To elucidate the precursors of the pyrim dine under anaerobic conditions, the incorporation of the labels of following compounds, [2,2,3,3-D] succinate, [1-^<13>C]glycine and [2-^<13>C]glycine, into the pyrimidine was studied. The labels of [2,2,3,3-D]succinate were not incorporated into the pyrimidine under anaerobic con ditions in E. coli and S. cerevisiae. These results suggested that succinate had no relation to the bio synthesis of the pyrimidine. The labels of[1-^<13>C]glycine and [2-^<13>C]glycine were incorporated into C-4 and C-6 of the pyrimi dine respectively under anaerobic conditions as well as aerobic conditions in E. coli. We already reported that N atom of glycine, the precursor of N-1 of the pyrimidine under aerobic conditions, was incorporated into it under anaerobic conditions. These results showed that glycine was the precursor of the pyrimidine under anaerobic conditions as well as aerobic conditions.
著者関連情報
© 1999 日本ビタミン学会

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
前の記事 次の記事
feedback
Top