Abstract
Thiamine content and its phosphorylation in several tissues of normal and alloxan diabetic rats were determined. They were considerably less in alloxan diabetic rats than in normal ones. After intravenous injection of thiamine the increase of the content of this vitamin was less in every tissue of diabetic animals than in that of normal. Its phosphorylation was also suppressed in the former. But, if insulin was administered prior to the injection of thiamine to the rats the content and the phosphorylation became the same as in the normal rats.
