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Yoshito NISHIZAWA
Article type: Article
1955 Volume 8 Pages
1-16
Published: 1955
Released on J-STAGE: December 22, 2017
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Koji NAITO, Takajiro MORI
Article type: Article
1955 Volume 8 Pages
17-20
Published: 1955
Released on J-STAGE: December 22, 2017
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In the assay procedure of the vitamin A added to margarine, coloring matters in the margarine which interfere with the experiment have to be removed by chromatography. The authors have found that yellow A. B. and O. B., the pigments which are permitted to use in Japan, become soluble in glacial acetic acid containing acetaldehyde, and devised a simple method of determining the content of vitamin A in margarine by applying the solubility. In this method, the vitamin A content in margarine is determined after the removal of pigments to the acetic acid layer by shaking a petroleum ether solution of unsaponifiable matter with glacial acetic acid containing acetaldehyde. The recovery of vitamin A by this method is over 96%.
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Mototeru YANO, Tadashi YAMAGUCHI
Article type: Article
1955 Volume 8 Pages
20-27
Published: 1955
Released on J-STAGE: December 22, 2017
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The thiamine and riboflavin contents of many varieties of foodstuffs have been repeatedly determined in order to revise the existing standard analytical table of Japanese foodstuffs.
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Katashi MAKINO, Takeo KINOSHITA
Article type: Article
1955 Volume 8 Pages
28-30
Published: 1955
Released on J-STAGE: December 22, 2017
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The oral administration of toxopyrimidine (2-methyl-6-amino-5-hydroxymethylpyrimidine) to mouse causes a specific convulsive fit. This toxic action is prevented by a preliminary administration of 2-methyl-6-hydroxy-5-hydroxymethylpyrimidine (DOP) or any of B_6-group vitamins. The activity of these atoxopyrimidine substances could be explained by the biological antagonists as shown in the chemical structures below. [chemical formula] The superiority of pyridoxin to pyridoxamine in atoxopyrimidine activity might be understood also by these chemical structures.
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Shinji ITOH
Article type: Article
1955 Volume 8 Pages
31-36
Published: 1955
Released on J-STAGE: December 22, 2017
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The effects of O, S-diacetyl thiamine (DAT) and dibenzyl thiamne (DBT) on the pieces of excized small intestine of the albino rat were examined. The addition of DAT to the suspension with intestines gives rise to contractions, but has no effect on those pretreated with atropine. The contraction are stronger when choline and DAT are given simultaneously, and glutathione and cysteine also have the same effect. Thiamine has to some extent a suppressing effect on the contraction of intestinal loops with acetylcholine, but DAT and thiamine-alkyldisulfide have no effect. The addition of DBT to the suspension of intestines results in relaxation and the responsibility of the intestine to acetylcholine, histamine or pituitrine is decreased.
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Kimiho IRINODA, Seizo SATO, Seiichi YAMADA
Article type: Article
1955 Volume 8 Pages
36-40
Published: 1955
Released on J-STAGE: December 22, 2017
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The relations between riboflavin-and niacin-deficincy were tested with rabbits. In the riboflavin deficient animals, the urinary excretion of riboflavin was very small. In this case even when riboflavin was administered, the excretion was still low, and the riboflavin content in organs was less than that of control animals, while in niacin deficiency the urinary excretion of niacin decreased, and in niacin-and riboflavin-deficiency the excretion of the vitamins in urine considerably decreased. In the case of niacin deficiency, even when riboflavin was administered, riboflavin content in blood and organs was low as compared with that of control animals. These results suggest that niacin and riboflavin would compensate each other and exert synergetic actions in the consumption of the vitamins in the body. There may be some indivisible relationship between the two vitamins, since riboflavin deficiency is given rise to by niacin deficiency.
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Ichiro NAKAGAWA, Konosuke TOMABECHI
Article type: Article
1955 Volume 8 Pages
41-44
Published: 1955
Released on J-STAGE: December 22, 2017
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In order to ascertain whether the angular stomatitis was caused by niacin or riboflavin deficiency or not, the curative effects of the administration of niacin, riboflavin, D-araboflavin, 6-methyl-9-β-hydroxyethyl-isoalloxazine, penicillin, etc. were observed on school children who had the deficiency symptoms. No proof was obtained with regard to that angular stomatitis was due to riboflavin or niacin deficiency.
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Eiichiro YAMAGATA
Article type: Article
1955 Volume 8 Pages
44-49
Published: 1955
Released on J-STAGE: December 22, 2017
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The influences of riboflavin (B_2) and riboflavin-5'-phosphate-diethanolamine(B_2-PE) on the renal function were compared each other, the glomerular filtration rate (G.F.R.) being taken as an indicator. Changes in G.F.R. and the quantity of urine due to an administration of 10mg. each of B_2 or B_2-PE were observed on six patients with liver trouble, five renal patients and two healthy control subjects. In healthy adults there was no significant difference in the G.F.R. and the quantity of urine between B_2 and B_2-PE. In renal and livery patients, more considerable increases of G.F.R. and the quantity of urine were noticed by administration of B_2-PE as compared with those by B_2. These results indicate that B_2-PE is more effective on the deteriorated renal function than B_2.
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Eiichiro YAMAGATA
Article type: Article
1955 Volume 8 Pages
49-55
Published: 1955
Released on J-STAGE: December 22, 2017
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This influence of vitamin B_<12> on the glomerular filtration were observed on three healthy subjects and 18 renal and livery patients. The administration of vitamin B_<12> had no effect on healthy subjects, while it produced increases in both glomerular filtration and volume of urine on the renal patients whose glomerular fitration had been lowered. Within the range of dose from 15μg. to 60μg., the more the dose, the more considerable the recovery of glomerular filtration.
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Eiichiro YAMAGATA
Article type: Article
1955 Volume 8 Pages
55-61
Published: 1955
Released on J-STAGE: December 22, 2017
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The influences of the administration of folic acid on the glomerular filtration rate were observed on three healthy persons and 18 renal and hepatic patients. Thirty mg of folic acid had no effect on healthy persons. No effect was also found in petients who had a normal rate of glomerular filtration. In the patients whose glomerular filtration had been lowered, a similar administration resulted in a marked rise. This result was more pronounced as the dose was raised.
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Kunio YAGI, Toshikazu TABATA, Etsu KOTAKI, Takeo ARAKAWA
Article type: Article
1955 Volume 8 Pages
61-63
Published: 1955
Released on J-STAGE: December 22, 2017
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The fluorospectra of riboflavin, FMN FAD, lumichrome, lumiflavin, Na-fluorescein, citrinin, etc. were measured using the spectrofluorometer devised by these authors and compared with those described in literature.
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Tadashi KAMIKUBO
Article type: Article
1955 Volume 8 Pages
64-67
Published: 1955
Released on J-STAGE: December 22, 2017
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The oxidation of vitamin B_<12> with hydrogenperoxide and hydrochloric acid was applied to the estimation of the so-called alkali stable factor in the bioassay of vitamin B_<12> using Lactobacillus leichmannii. The true vitamin B_<12> value might be obtained from the difference between the apparent vitamin B_<12> value and the activity remaininng after the treatment, since vitamin B_<12> is destroyed by the oxidation according to Beiler, while the alkali stable factor is left unchanged by the treatment. Sodium chloride produced in the treatment was found to exert no toxic effect on Lactobacillus leichmannii within the range of the determination. The satisfactory results were obtained also with several natural materials.
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Eijiro SATOYOSHI
Article type: Article
1955 Volume 8 Pages
68-75
Published: 1955
Released on J-STAGE: December 22, 2017
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In rabbits changes in the thiamine concentrations in the liver, kidney, heart, lung, spleen and adrenal body were observed when the autonomic nervous center in the hypothalamus was stimulated. The stimulation of sympathetic center caused a considerable decrease of the total thiamine content in the liver after 40-60 minutes and in the kidney after 40 minutes. The decrease was slight in the lung after 40-60 minutes and little or no change in the heart, spleen and adrenal. Decrease of free thiamine were recognized in the other organs owing to the low content of the vitamin in them. No significant change was recognized in the contents of free and total thiamine of each organ in stimulating the parasympathetic center.
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Eijiro SATOYOSHI
Article type: Article
1955 Volume 8 Pages
76-80
Published: 1955
Released on J-STAGE: December 22, 2017
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Investigations on the thiamine concentrations in blood and urine of patients with congestive heart failure, compensated heart failure and other heart diseases without edema were conducted. When thiamine was administered, the thiamine concentrations in blood and urine were normal in the patients with heart failure. But without giving the thiamine, the concentrations were considerably lower as compared with the normal levels. They appear therefore to suffer from thiamine deficiency. The rate of thiamine excretion in the above patients was always low even when administered with vitamin. No thiamine deficiency was rocognized in compensated heart failures. Thiamine deficiency was also found in patients with severe other diseases, but in most of them hydremia was found contrary to the patients with heart failure.
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Eijiro SATOYOSHI
Article type: Article
1955 Volume 8 Pages
81-84
Published: 1955
Released on J-STAGE: December 22, 2017
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Changes of the urinary elimination of thiamine were observed on patient with heart failure to whom diuretics such as digitalis preparations, ion exchange resins and mercury preparations were administered. Generally speaking a remarkable increase of the elimination of thiamine was found whenever diuresis took place.
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
84-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
84-
Published: 1955
Released on J-STAGE: December 22, 2017
JOURNAL
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
84-
Published: 1955
Released on J-STAGE: December 22, 2017
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Shoichi TATSUNO, Takiji SAWAFUJI, Bunichi SAITO
Article type: Article
1955 Volume 8 Pages
85-89
Published: 1955
Released on J-STAGE: December 22, 2017
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In 46 patients of various diseases, chiefly of tuberculosis, the urine at early morning and after intravenous injection of 100mg. of ascorbic acid were used for the determination of ascorbic acid and the detection of phenylalanine. The results indicated that the ascorbic acid contents of the urine at early morning was distinctly less as compared with that of control healthy subjects, and more than half of the patients were suffering from severe avitaminosis. The amount of ascorbic acid in the urine in seven hours after the parenteral administration of the vitamin was also less than that of control subjects. Phenylalanine in the urine was positive in 30% of the patients, and especially in a chronic nephritis with nephrosis it was remarkably positive, and the amount of ascorbic acid in the urine after the administration of the vitamin was also small. Thus there may be exist some correlation between the asorbic acid content and the appearance of phenylalanine in the urine.
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
89-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
89-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
89-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
90-91
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
91-92
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
92-93
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
93-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
93-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
93-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
93-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
94-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
94-95
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
95-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
95-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
95-96
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
96-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
96-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
96-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
97-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
97-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
97-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
97-98
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
98-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
98-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
98-99
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
99-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
99-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
99-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
99-100
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese], [in Japanese]
Article type: Article
1955 Volume 8 Pages
100-
Published: 1955
Released on J-STAGE: December 22, 2017
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[in Japanese]
Article type: Article
1955 Volume 8 Pages
100-
Published: 1955
Released on J-STAGE: December 22, 2017
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